Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7879607 | 0.89 | ADRB1 (0.52) | ADRB1RAB9APOLBCYP19A1 | |
| SCHEMBL7875306 | 0.87 | ADRB1 (0.51) | ADRB1RAB9APOLBCYP3A4 | |
| SCHEMBL7873818 | 0.82 | PKM (0.59) | LMNAPKMPOLBCYP3A4 | |
| SCHEMBL7868666 | 0.81 | ADRA2C (0.46) | LMNACYP19A1ADRA2C | |
| Hydrochloric Acid SCHEMBL7903386 | 0.81 | PKM (0.58) | LMNAPKMPOLBCYP3A4 | |
| SCHEMBL10830342 | 0.80 | POLB (0.67) | RAB9APKMPOLBCYP19A1ADRA2C | |
| SCHEMBL7875310 | 0.76 | ADRB1 (0.42) | ADRB1RAB9APOLBCYP3A4 | |
| SCHEMBL11420443 | 0.76 | ADRA2C (0.52) | LMNACYP19A1ADRA2CCYP3A4 | |
| SCHEMBL11332915 | 0.75 | PKM (0.46) | RAB9APKMPOLBCYP19A1ADRA2C | |
| SCHEMBL11070436 | 0.75 | LMNA (0.44) | RAB9ALMNAPKMPOLBCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6326500-B1 | ANTIINFLAMMATORY AGENTS; ANTIALLERGENS | ABBOTT LABORATORIES | 2001-12-04 | — | — | US | disclosed |
| US-6215001-B1 | ANTIINFLAMMATORY AGENTS, ANTIASTHMATICS, AND ANTIALLERGENS; SIDE EFFECT REDUCTION | KNOLL AKTIENGESELLSCHAFT (DE) | 2001-04-10 | — | — | US | disclosed |
| US-6031109-A | Phenoxy-, phenylthio-, benzoyl-alkyleneaminoalkylene-imidazole derivatives as therapeutic agents | KNOLL AKTIENGESELLSCHAFT (DE) | 2000-02-29 | — | — | US | disclosed |
| US-5780642-A | NON-STEROIDAL ANTIINFLAMMATORY AGENT WHICH BLOCKS RELEASE OF ARACHIDONIC ACID FROM PHOSPHOLIPIDS; SIDE EFFECT REDUCTION | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-07-14 | — | — | US | disclosed |
| EP-0705251-A1 | IMIDAZOLE DERIVATIVES AS THERAPEUTIC AGENTS | Knoll AG (DE) | 1996-04-10 | — | — | EP | disclosed |
| WO-1995000493-A1 | IMIDAZOLE DERIVATIVES AS THERAPEUTIC AGENTS | KNOLL AG (DE) | 1995-01-05 | — | — | WO | disclosed |