Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 9/20 | 0.59 |
| ▸ | GRK2 | P25098 | 5/20 | 0.59 |
| ▸ | RECQL | P46063 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MMP2 | P08253 | 1/20 | 0.56 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MMP1 | P03956 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.54 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.54 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014867 | 0.85 | POLB (0.52) | POLBGRK2RECQLLMNAMAPK1 | |
| SCHEMBL7874157 | 0.85 | KMT2A (0.71) | POLBLMNAMAPK1KMT2AALDH1A1 | |
| SCHEMBL7874122 | 0.84 | KMT2A (0.58) | POLBGRK2RECQLLMNAKMT2A | |
| SCHEMBL7870908 | 0.83 | ALDH1A1 (0.62) | POLBLMNAKMT2AKDM4EALDH1A1 | |
| SCHEMBL28897130 | 0.83 | KMT2A (0.53) | POLBLMNAKMT2AKDM4ETDP1 | |
| SCHEMBL7874047 | 0.83 | KMT2A (0.53) | POLBLMNAKMT2AKDM4EALDH1A1 | |
| SCHEMBL28101227 | 0.83 | MAPT (0.59) | LMNAKMT2AL3MBTL1MMP1HSD11B1 | |
| SCHEMBL13299623 | 0.83 | PLCG1 (0.52) | POLBGRK2RECQLLMNAMAPK1 | |
| SCHEMBL7017241 | 0.83 | KMT2A (0.54) | POLBGRK2RECQLLMNAMAPK1 | |
| SCHEMBL16144557 | 0.82 | KMT2A (0.57) | POLBGRK2LMNAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994104-A1 | ARYL (SULFIDE, SULFOXIDE AND SULFONE) DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-04-19 | — | — | EP | claimed |
| US-6300514-B1 | INHIBITING MATRIX METALLOPROTEINASES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-10-09 | — | — | US | disclosed |
| EP-0994104-A1 | ARYL (SULFIDE, SULFOXIDE AND SULFONE) DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-04-19 | — | — | EP | disclosed |