Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 2/20 | 0.46 |
| ▸ | NOS3 | P29474 | 2/20 | 0.43 |
| ▸ | NOS2 | P35228 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SLC2A4 | P14672 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7875011 | 0.88 | NOS1 (0.49) | NOS1NOS3NOS2MAPTNPSR1 | |
| SCHEMBL7873162 | 0.88 | NOS1 (0.49) | NOS1NOS2MAPTNPSR1GRIN2D | |
| SCHEMBL7874966 | 0.86 | CYP3A4 (0.51) | NOS1NOS3NOS2MAPTNPSR1 | |
| SCHEMBL14367988 | 0.84 | SIGMAR1 (0.54) | MAPTMEN1KMT2AGRIN2DGRIN3B | |
| SCHEMBL7865754 | 0.84 | PDK1 (0.51) | MAPTNPSR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL5080879 | 0.82 | LOXL2 (0.49) | NOS1NOS3NOS2GRIN2DGRIN3B | |
| Hydrochloric Acid SCHEMBL7875006 | 0.81 | LOXL2 (0.47) | NOS1NOS3NOS2GRIN2DGRIN3B | |
| SCHEMBL7873185 | 0.81 | TRPV1 (0.46) | MAPTNPSR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL7865767 | 0.80 | POLB (0.47) | MAPTMEN1KMT2ACYP1A2RAB9A | |
| SCHEMBL5078291 | 0.79 | NOS1 (0.49) | NOS1NOS3NOS2GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37438-E1 | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase | GLAXO WELLCOME INC. | 2001-11-06 | — | — | US | disclosed |
| US-5866612-A | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase | GLAXO WELLCOME INC. (US) | 1999-02-02 | — | — | US | disclosed |