Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.56 |
| ▸ | MMP13 | P45452 | 2/20 | 0.56 |
| ▸ | MMP7 | P09237 | 1/20 | 0.56 |
| ▸ | ACE | P12821 | 1/20 | 0.56 |
| ▸ | MMP12 | P39900 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28236883 | 0.83 | LMNA (0.52) | MMP1MMP13MMP7ACEMMP12 | |
| SCHEMBL8905441 | 0.79 | LMNA (0.55) | MMP1MMP13MMP7ACEMMP12 | |
| SCHEMBL2625200 | 0.77 | LMNA (0.57) | MMP1MMP13MMP7ACEMMP12 | |
| SCHEMBL4629467 | 0.74 | GAA (0.61) | L3MBTL1LMNAPKMKDM4EALDH1A1 | |
| SCHEMBL26343879 | 0.74 | LMNA (0.53) | MMP1MMP13MMP7ACEMMP12 | |
| SCHEMBL11763613 | 0.73 | LMNA (0.57) | L3MBTL1LMNAPKMALDH1A1GAA | |
| SCHEMBL9732646 | 0.73 | LMNA (0.57) | MMP1MMP13MMP7ACEMMP12 | |
| SCHEMBL20869721 | 0.72 | L3MBTL1 (0.60) | L3MBTL1LMNAPKMALDH1A1GAA | |
| Butane SCHEMBL7376315 | 0.72 | MMP1 (0.49) | MMP1MMP13MMP7ACEMMP12 | |
| SCHEMBL2448076 | 0.72 | MMP1 (0.51) | MMP1MMP13MMP7ACEMMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001051095-A2 | PARAMAGNETIC DOTA DERIVATIVES, PHARMACEUTICAL AGENTS CONTAINING THE SAME, METHODS FOR THE PRODUCTION THEREOF AND THEIR USE FOR THE MR IMAGING OF NECROSIS AND INFARCTION | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-07-19 | — | — | WO | disclosed |