Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP7 | P09237 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 1/20 | 0.48 |
| ▸ | MMP12 | P39900 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2625200 | 0.86 | LMNA (0.57) | LMNAL3MBTL1MMP1MMP7ACE | |
| SCHEMBL6008513 | 0.80 | L3MBTL1 (0.64) | LMNAL3MBTL1HTR2CATMF2 | |
| SCHEMBL26343879 | 0.79 | LMNA (0.53) | LMNAL3MBTL1MMP1MMP7ACE | |
| SCHEMBL7875236 | 0.79 | MMP1 (0.56) | LMNAL3MBTL1MMP1MMP7ACE | |
| SCHEMBL11763613 | 0.78 | LMNA (0.57) | LMNAL3MBTL1HTR2CHTR6ATM | |
| SCHEMBL9732646 | 0.78 | LMNA (0.57) | LMNAL3MBTL1MMP1MMP7ACE | |
| SCHEMBL28236883 | 0.78 | LMNA (0.52) | LMNAL3MBTL1MMP1MMP7ACE | |
| SCHEMBL12418684 | 0.77 | ABL1 (0.50) | LMNAL3MBTL1MMP1MMP7ACE | |
| SCHEMBL26343857 | 0.77 | HTT (0.53) | LMNAL3MBTL1ATMPKMTSHR | |
| SCHEMBL9043455 | 0.76 | LMNA (0.50) | LMNAL3MBTL1MMP1MMP7ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684029-A | HYPOTENSIVE AGENTS | KARL THOMAE GMBH (DE) | 1997-11-04 | — | — | US | disclosed |
| US-5587393-A | ANGIOTENSIN ANTAGONIST USEFUL IN TREATING HYPERTENSION | DR. KARL THOMAE GMBH (DE) | 1996-12-24 | — | — | US | disclosed |
| US-5385925-A | Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1995-01-31 | — | — | US | disclosed |