Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7872781 | 0.85 | TLR8 (0.44) | HTR2AIKBKB | |
| SCHEMBL10202508 | 0.79 | REN (0.38) | HTR2A | |
| SCHEMBL7863962 | 0.74 | HTR2A (0.43) | HTR2AHTR2C | |
| SCHEMBL7867597 | 0.73 | CHRNB2 (0.46) | HTR2A | |
| SCHEMBL7872529 | 0.69 | REN (0.41) | HTR2AIKBKB | |
| SCHEMBL7863795 | 0.69 | REN (0.54) | HTR2AIKBKB | |
| SCHEMBL7865968 | 0.68 | CHRNB2 (0.42) | IKBKB | |
| SCHEMBL16446427 | 0.67 | HTR2A (0.59) | HTR2AIKBKBHTR2C | |
| SCHEMBL7863764 | 0.67 | REN (0.58) | IKBKB | |
| SCHEMBL26938735 | 0.67 | HTR2A (0.54) | HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |