Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 2/20 | 0.47 |
| ▸ | ALPI | P09923 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | NOS3 | P29474 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10376372 | 0.74 | ALPL (0.51) | ALPLALPIADRA2BDRD1KCNH2 | |
| SCHEMBL10377977 | 0.73 | ALPL (0.50) | ALPLALPIADRA2BDRD1KCNH2 | |
| SCHEMBL809711 | 0.67 | NOS1 (0.46) | ALPLALPIADRA2BDRD1KCNH2 | |
| SCHEMBL10455191 | 0.66 | NOS1 (0.49) | ALPLALPIADRA2BDRD1KCNH2 | |
| Hydrochloric Acid SCHEMBL10378355 | 0.65 | ALPL (0.47) | ALPLALPIADRA2BDRD1KCNH2 | |
| SCHEMBL3436548 | 0.64 | NOTUM (0.59) | ALDH1A1LMNASLC18A3NOTUMKCNA3 | |
| SCHEMBL17392707 | 0.64 | NOTUM (0.59) | ALDH1A1LMNASLC18A3NOTUMKCNA3 | |
| SCHEMBL6398487 | 0.64 | NOTUM (0.59) | ALDH1A1LMNASLC18A3NOTUMKCNA3 | |
| Hydrochloric Acid SCHEMBL10376392 | 0.64 | ALPL (0.46) | ALPLALPIADRA2BDRD1KCNH2 | |
| Dexamisole SCHEMBL123414 | 0.64 | ALPL (1.00) | ALPLALPIADRA2BDRD1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869127-B1 | Bicyclic amidines and their use as catalysts | LONZA AG (CH) | 2001-10-10 | — | — | EP | claimed |
| EP-0869127-A1 | Bicyclic amidines and their use as catalysts | LONZA AG (CH) | 1998-10-07 | — | — | EP | claimed |