Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7884126 | 0.83 | HTR1A (0.52) | HTR1ASLC6A4ADRB2 | |
| SCHEMBL8554333 | 0.77 | SIGMAR1 (0.45) | DRD2 | |
| SCHEMBL7884073 | 0.75 | HTR2A (0.52) | HTR1ASLC6A4DRD2DRD4DRD3 | |
| SCHEMBL6621730 | 0.73 | TDP1 (0.48) | HTR1ASLC6A4DRD4DRD3MEN1 | |
| SCHEMBL7883032 | 0.72 | CCR1 (0.48) | HTR1ASLC6A4DRD2DRD4DRD3 | |
| SCHEMBL7885696 | 0.72 | HTR1A (0.41) | HTR1ASLC6A4DRD2DRD4DRD3 | |
| SCHEMBL5243103 | 0.71 | HTR1A (0.58) | HTR1ASLC6A4DRD2DRD4DRD3 | |
| SCHEMBL7887491 | 0.71 | HTR1A (0.44) | HTR1ASLC6A4DRD2DRD4DRD3 | |
| SCHEMBL8397976 | 0.70 | HTR1A (0.45) | HTR1ASLC6A4DRD2DRD4DRD3 | |
| SCHEMBL29062924 | 0.70 | HTR1A (0.55) | HTR1ASLC6A4DRD4HTR1BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172073-B1 | BENZIMIDAZOLYLOXY ALKANAMINES AS SEROTONIN REUPTAKE INHIBITORS; NICOTINE AND TOBACCO WITHDRAWAL; PSYCHOLOGICAL, EATING, BRAIN, GASTROINTESTINAL, SLEEP, AND SEXUAL DISORDERS | ELI LILLY AND COMPANY | 2001-01-09 | — | — | US | disclosed |
| US-5627196-A | ANTIDEPRESSANTS AND ANTISEROTONIN AGENTS | ELI LILLY AND COMPANY (US) | 1997-05-06 | — | — | US | disclosed |
| US-5614523-A | INDOLYLOXY COMPOUNDS | ELI LILLY AND COMPANY (US) | 1997-03-25 | — | — | US | disclosed |
| US-5576321-A | ALKOXY-SUBSTITUTED INDOLES | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| EP-0722941-A2 | Compounds having effects on serotonin-related systems | ELI LILLY AND COMPANY (US) | 1996-07-24 | — | — | EP | disclosed |