Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7431665 | 0.91 | SIGMAR1 (0.54) | SIGMAR1GRIN2BOPRM1DRD2HTR2A | |
| SCHEMBL8554337 | 0.85 | DRD2 (0.38) | SIGMAR1GRIN1GRIN2BDRD2HTR2A | |
| SCHEMBL7952645 | 0.82 | SIGMAR1 (0.59) | SIGMAR1OPRM1DRD2HTR2A | |
| SCHEMBL7437439 | 0.82 | SIGMAR1 (0.42) | SIGMAR1 | |
| SCHEMBL7876353 | 0.77 | HTR1A (0.44) | DRD2 | |
| SCHEMBL7435075 | 0.76 | TMEM97 (0.75) | SIGMAR1 | |
| SCHEMBL467160 | 0.75 | GRIN1 (0.70) | SIGMAR1GRIN1GRIN2B | |
| SCHEMBL19852259 | 0.74 | OPRM1 (0.39) | SIGMAR1OPRM1 | |
| SCHEMBL8010301 | 0.74 | GRIN1 (0.68) | GRIN1GRIN2B | |
| SCHEMBL8010239 | 0.74 | GRIN1 (0.68) | GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649407-B1 | DIMERIC PIPERIDINE, TETRAHYDROPYRIDINE AND PIPERAZINE DERIVATIVES | LUNDBECK & CO AS H (DK) | 1998-08-05 | — | — | EP | claimed |