SCHEMBL7876442

SCHEMBL7876442

COC(=O)c1sc(-c2ccccc2F)c(-c2ccc(SC)cc2)c1CBr

nearest known ligand 0.43

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.43
NPC1 O15118 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
UBE2N P61088 1/20 0.38
MAPT P10636 2/20 0.38
SLC6A3 Q01959 2/20 0.37
SLC6A4 P31645 1/20 0.37
MAPK14 Q16539 1/20 0.36
BDKRB1 P46663 8/20 0.36
CTSK P43235 1/20 0.35
GRIA2 P42262 1/20 0.34
GRIA4 P48058 1/20 0.34
GNRHR P30968 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7874964 0.86 L3MBTL1 (0.49) L3MBTL1NPC1TDP1UBE2NMAPT
SCHEMBL7869544 0.85 L3MBTL1 (0.43) L3MBTL1NPC1TDP1UBE2NMAPT
SCHEMBL7869535 0.75 L3MBTL1 (0.47) L3MBTL1NPC1TDP1UBE2NMAPT
SCHEMBL7874913 0.69 PTGS2 (0.49)
SCHEMBL8985251 0.68 MAPK14 (0.47) L3MBTL1NPC1TDP1MAPTMAPK14
SCHEMBL6050765 0.66 IKBKB (0.46) L3MBTL1NPC1TDP1UBE2NMAPT
SCHEMBL6050848 0.66 IKBKB (0.46) L3MBTL1NPC1TDP1UBE2NMAPT
SCHEMBL8652108 0.66 L3MBTL1 (0.50) L3MBTL1NPC1TDP1UBE2NSLC6A3
SCHEMBL9203812 0.65 MAPT (0.49) L3MBTL1MAPT
SCHEMBL8650648 0.65 L3MBTL1 (0.52) L3MBTL1NPC1TDP1UBE2NMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6329421-B1 PHENYL-SUBSTITUTED BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES; NONSTEROIDAL ANTIINFLAMMATORY AGENTS MERCK FROSST CANADA & CO. (CA) 2001-12-11 US disclosed
EP-0778834-B1 DIARYL BICYCLIC HETEROCYCLES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA INC (CA) 2000-01-26 EP disclosed
EP-0778834-A1 DIARYL BICYCLIC HETEROCYCLES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA INC. (CA) 1997-06-18 EP disclosed
US-5521213-A NONSTEROID ANTIINFLAMMATORY AGENTS MERCK FROSST CANADA, INC. (CA) 1996-05-28 US disclosed
WO-1996006840-A1 DIARYL BICYCLIC HETEROCYCLES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA INC. (CA) 1996-03-07 WO disclosed