Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | UBE2N | P61088 | 1/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | GRM6 | O15303 | 2/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7869544 | 0.90 | L3MBTL1 (0.43) | L3MBTL1TDP1NPC1UBE2NGRM6 | |
| SCHEMBL7876442 | 0.86 | L3MBTL1 (0.43) | L3MBTL1TDP1NPC1UBE2NGRIA4 | |
| SCHEMBL7869535 | 0.86 | L3MBTL1 (0.47) | L3MBTL1TDP1NPC1UBE2NPLA2G1B | |
| SCHEMBL8800287 | 0.74 | GRIA4 (0.49) | L3MBTL1TDP1NPC1GRIA4ALDH1A1 | |
| SCHEMBL7874913 | 0.73 | PTGS2 (0.49) | KDM4EHPGDHSD17B10 | |
| SCHEMBL7874918 | 0.71 | NPC1 (0.39) | L3MBTL1TDP1NPC1GRM6GRIA4 | |
| SCHEMBL8650648 | 0.69 | L3MBTL1 (0.52) | L3MBTL1TDP1NPC1UBE2NALDH1A1 | |
| SCHEMBL2063437 | 0.69 | ALDH1A1 (0.48) | L3MBTL1TDP1PLA2G1BATG4BTRPM8 | |
| SCHEMBL7874965 | 0.68 | PTGS1 (0.45) | L3MBTL1TDP1NPC1UBE2NGRIA4 | |
| SCHEMBL27592419 | 0.68 | ALDH1A1 (0.54) | L3MBTL1TDP1PLA2G1BATG4BTRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329421-B1 | PHENYL-SUBSTITUTED BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES; NONSTEROIDAL ANTIINFLAMMATORY AGENTS | MERCK FROSST CANADA & CO. (CA) | 2001-12-11 | — | — | US | disclosed |
| EP-0778834-B1 | DIARYL BICYCLIC HETEROCYCLES AS INHIBITORS OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA INC (CA) | 2000-01-26 | — | — | EP | disclosed |
| US-5521213-A | NONSTEROID ANTIINFLAMMATORY AGENTS | MERCK FROSST CANADA, INC. (CA) | 1996-05-28 | — | — | US | disclosed |