Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6056906 | 0.76 | RAB9A (0.55) | RAB9ANPC1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL10467309 | 0.75 | — | — | |
| SCHEMBL7868165 | 0.74 | SMN1; SMN2 (0.58) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6424749 | 0.74 | NPC1 (0.54) | RAB9ANPC1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL12599389 | 0.74 | NR3C1 (0.53) | RAB9ANPC1SMN1; SMN2LMNANR3C1 | |
| SCHEMBL564354 | 0.73 | — | — | |
| SCHEMBL7874773 | 0.72 | RAB9A (0.49) | RAB9ANPC1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL19974323 | 0.71 | NPC1 (0.58) | RAB9ANPC1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL19974322 | 0.71 | NPC1 (0.58) | RAB9ANPC1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL7876547 | 0.71 | FFAR2 (0.52) | RAB9ANPC1SMN1; SMN2LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |