Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | HTR2C | P28335 | 5/20 | 0.51 |
| ▸ | HTR6 | P50406 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | HTR3A | P46098 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 3/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5138986 | 0.80 | SIGMAR1 (0.51) | SIGMAR1HTR2CHTR6MAPTHTR2A | |
| SCHEMBL8819830 | 0.79 | HTR6 (0.43) | SIGMAR1HTR2CHTR6MAPTHTR1B | |
| SCHEMBL7864911 | 0.72 | SIGMAR1 (0.51) | SIGMAR1HTR2CHTR6MAPTHTR1B | |
| SCHEMBL7859749 | 0.70 | HTR6 (0.45) | SIGMAR1HTR2CHTR6MAPTHTR1B | |
| SCHEMBL531984 | 0.70 | SIGMAR1 (1.00) | SIGMAR1HTR2CHTR6MAPTHTR1B | |
| SCHEMBL6599102 | 0.70 | HTR2C (0.65) | SIGMAR1HTR2CHTR6MAPTHTR1B | |
| SCHEMBL9032554 | 0.70 | HTR2C (0.58) | SIGMAR1HTR2CHTR6MAPTHTR1B | |
| SCHEMBL7866446 | 0.69 | CCNT1 (0.49) | CDK9CCNT1 | |
| Hydrochloric Acid SCHEMBL652812 | 0.69 | HTR2C (1.00) | SIGMAR1HTR2CHTR6MAPTHTR1B | |
| SCHEMBL4329636 | 0.68 | HTR2C (0.60) | SIGMAR1HTR2CHTR6MAPTHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172073-B1 | BENZIMIDAZOLYLOXY ALKANAMINES AS SEROTONIN REUPTAKE INHIBITORS; NICOTINE AND TOBACCO WITHDRAWAL; PSYCHOLOGICAL, EATING, BRAIN, GASTROINTESTINAL, SLEEP, AND SEXUAL DISORDERS | ELI LILLY AND COMPANY | 2001-01-09 | — | — | US | disclosed |
| US-5789402-A | Compounds having effects on serotonin-related systems | ELI LILLY COMPANY (US) | 1998-08-04 | — | — | US | disclosed |
| US-5741789-A | HETERO-OXY ALKANAMINES | ELI LILLY AND COMPANY (US) | 1998-04-21 | — | — | US | disclosed |
| CN-1178530-A | Compounds having an effect on 5-hydroxytryptamine related systems | LILLY CO ELI (US) | 1998-04-08 | — | — | CN | disclosed |
| US-5627196-A | ANTIDEPRESSANTS AND ANTISEROTONIN AGENTS | ELI LILLY AND COMPANY (US) | 1997-05-06 | — | — | US | disclosed |
| US-5614523-A | INDOLYLOXY COMPOUNDS | ELI LILLY AND COMPANY (US) | 1997-03-25 | — | — | US | disclosed |
| US-5576321-A | ALKOXY-SUBSTITUTED INDOLES | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| EP-0722941-A2 | Compounds having effects on serotonin-related systems | ELI LILLY AND COMPANY (US) | 1996-07-24 | — | — | EP | disclosed |