Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 5/20 | 0.40 |
| ▸ | NNMT | P40261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 5/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7868094 | 0.77 | TP53 (0.57) | SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL2446207 | 0.76 | ALDH1A1 (0.53) | KITNNMTSMN1; SMN2CDK8HDAC1 | |
| SCHEMBL7024674 | 0.75 | KDM4E (0.51) | SMN1; SMN2NPC1RAB9APOLBGAA | |
| SCHEMBL2081651 | 0.74 | SMN1; SMN2 (0.50) | NNMTSMN1; SMN2MAPK14CDK8HDAC1 | |
| SCHEMBL29403604 | 0.74 | SMN1; SMN2 (0.50) | NNMTSMN1; SMN2MAPK14CDK8HDAC1 | |
| SCHEMBL4942948 | 0.73 | NAMPT (0.51) | KIT | |
| SCHEMBL31190971 | 0.73 | NAMPT (0.51) | KIT | |
| SCHEMBL18291750 | 0.73 | GABRP (0.48) | KITNNMTSMN1; SMN2BRAFCDK8 | |
| SCHEMBL1691584 | 0.72 | GABRP (0.52) | KITNNMTSMN1; SMN2MAPK14KDR | |
| SCHEMBL7876593 | 0.72 | CIT (0.48) | KITNNMTSMN1; SMN2BRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |