Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7881578 | 1.00 | GPR119 (0.36) | GPR119ADRA1ASMN1; SMN2NPC1TP53 | |
| SCHEMBL7877057 | 0.87 | GPR119 (0.43) | GPR119NPC1RAB9APDE10AHPGD | |
| SCHEMBL505548 | 0.85 | ALOX15 (0.45) | SMN1; SMN2NPC1TP53TSHRRAB9A | |
| SCHEMBL505401 | 0.81 | GRM5 (0.44) | SMN1; SMN2NPC1TP53TSHRRAB9A | |
| SCHEMBL505085 | 0.80 | GRM5 (0.38) | ADRA1ASMN1; SMN2NPC1TP53TSHR | |
| SCHEMBL505082 | 0.80 | NPC1 (0.45) | GPR119SMN1; SMN2NPC1TP53TSHR | |
| SCHEMBL10250549 | 0.79 | TP53 (0.45) | GPR119ADRA1ASMN1; SMN2NPC1TP53 | |
| SCHEMBL505629 | 0.77 | KDM4E (0.40) | ADRA1ASMN1; SMN2NPC1TP53TSHR | |
| SCHEMBL7883808 | 0.77 | GPR119 (0.44) | GPR119NPC1RAB9AHPGDMAPT | |
| SCHEMBL7880996 | 0.76 | RAB9A (0.43) | GPR119ADRA1ASMN1; SMN2NPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114971-A1 | COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF | SEPRACOR INC. (US) | 2010-10-07 | — | — | WO | disclosed |