Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 2/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7879178 | 0.77 | ACE (0.39) | ACEHPGDPTPN1 | |
| SCHEMBL7903959 | 0.72 | ACE (0.53) | ACE | |
| SCHEMBL7876890 | 0.71 | ACE (0.38) | ACE | |
| SCHEMBL7879214 | 0.69 | SLC1A3 (0.49) | ACEPKM | |
| SCHEMBL7387885 | 0.64 | TLL1 (0.42) | ACEPKMLMNA | |
| SCHEMBL7876539 | 0.64 | SMN1; SMN2 (0.46) | ACECYP3A4HPGD | |
| SCHEMBL7868080 | 0.64 | TLL1 (0.43) | — | |
| SCHEMBL15592495 | 0.63 | FDPS (0.50) | PKMLMNA | |
| SCHEMBL7879226 | 0.63 | BMP1 (0.47) | ACE | |
| SCHEMBL7874743 | 0.63 | CYP2C19 (0.48) | MMP3MMP9ADAM17PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |