Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874806 | 0.89 | PPARA (0.45) | KMT2ALMNAMEN1HTT | |
| SCHEMBL4290877 | 0.86 | GRIK1 (0.43) | GRIK1ALOX5KMT2ACYP2D6CYP2C9 | |
| SCHEMBL7879161 | 0.86 | GRIK1 (0.43) | GRIK1ALOX5KMT2ACYP2D6CYP2C9 | |
| SCHEMBL7873373 | 0.83 | LTB4R (0.44) | ALOX5KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7879226 | 0.82 | BMP1 (0.47) | GRIK1ALOX5SMN1; SMN2 | |
| SCHEMBL7876532 | 0.82 | LTB4R (0.46) | ALOX5LTB4R | |
| SCHEMBL7387885 | 0.81 | TLL1 (0.42) | GRIK1ALOX5CYP2C9CYP2C19LMNA | |
| SCHEMBL3252245 | 0.80 | GRIK1 (0.51) | GRIK1KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7953565 | 0.80 | FDFT1 (0.43) | — | |
| SCHEMBL7876539 | 0.78 | SMN1; SMN2 (0.46) | KMT2ACYP2C9CYP2C19HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | claimed |
| US-6172064-B1 | METALLOPROTEASE INHIBITOR; ANTIARTHRITIC AGENTS, ANTIDIABETIC AGENTS; ANTITUMOR AGENTS | GLAXO WELLCOME INC. | 2001-01-09 | — | — | US | claimed |