Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 4/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7884054 | 0.82 | ADRA2B (0.40) | GRM2ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL7875245 | 0.81 | GRM2 (0.40) | GRM2PIM1 | |
| SCHEMBL7879169 | 0.81 | CCNB2 (0.36) | GRM2ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL7876318 | 0.80 | GRM2 (0.31) | GRM2 | |
| SCHEMBL7886812 | 0.80 | TDO2 (0.40) | — | |
| SCHEMBL7882339 | 0.80 | MAPT (0.35) | GRM2 | |
| SCHEMBL7884632 | 0.78 | NMT1 (0.37) | ADORA3ADORA2AADORA2BADORA1PIM1 | |
| SCHEMBL7879380 | 0.78 | P2RX7 (0.36) | GRM2 | |
| SCHEMBL7882812 | 0.78 | GRM2 (0.40) | GRM2 | |
| SCHEMBL7882669 | 0.78 | RORC (0.38) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114726-A1 | AMINOBENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |