Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.47 |
| ▸ | BTK | Q06187 | 5/20 | 0.46 |
| ▸ | ITK | Q08881 | 5/20 | 0.46 |
| ▸ | BRAF | P15056 | 3/20 | 0.46 |
| ▸ | IGF1R | P08069 | 2/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4570630 | 0.90 | BTK (0.48) | RIPK1BTKITKBRAFAXL | |
| SCHEMBL298060 | 0.86 | CYP2C9 (0.51) | RIPK1BTKITKBRAFIGF1R | |
| SCHEMBL7872452 | 0.86 | AAK1 (0.51) | RIPK1BTKITKAXLKIT | |
| SCHEMBL7875664 | 0.86 | RIPK1 (0.46) | RIPK1BTKITKBRAFIGF1R | |
| SCHEMBL858764 | 0.84 | AXL (0.58) | ITKBRAFAXLKITNTRK1 | |
| SCHEMBL7879446 | 0.84 | AXL (0.58) | RIPK1ITKBRAFAXLKIT | |
| SCHEMBL298899 | 0.83 | CAMKK2 (0.56) | RIPK1BRAFAXLKITPAK1 | |
| SCHEMBL298672 | 0.81 | AXL (0.52) | RIPK1BTKITKBRAFAXL | |
| SCHEMBL857559 | 0.81 | KIT (0.54) | RIPK1BRAFIGF1RAXLKIT | |
| SCHEMBL20086218 | 0.81 | DYRK1A (0.56) | RIPK1BRAFAXLNTRK1PAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129570-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. (US) | 2010-11-11 | — | — | WO | disclosed |