Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PRSS12 | P56730 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7670984 | 0.76 | LOXL2 (0.43) | TDP1LMNAKMT2AGAALOXL2 | |
| SCHEMBL7662062 | 0.74 | MAPT (0.55) | TDP1PRSS12KMT2AGAALOXL2 | |
| SCHEMBL7662066 | 0.74 | LOXL2 (0.41) | LMNAPRSS12KMT2AGAALOXL2 | |
| SCHEMBL7659816 | 0.74 | ESR1 (0.44) | KMT2AGAALOXL2MAPTSMN1; SMN2 | |
| SCHEMBL7666527 | 0.72 | NPC1 (0.43) | TDP1LMNAKMT2ALOXL2MAPT | |
| SCHEMBL7667320 | 0.70 | LOXL2 (0.43) | TDP1LMNAKMT2AGAALOXL2 | |
| SCHEMBL8115743 | 0.69 | TDP1 (0.49) | TDP1LMNAKMT2ACYP11B1CYP11B2 | |
| SCHEMBL7661911 | 0.69 | LOXL2 (0.42) | TDP1GAALOXL2MAPTALDH1A1 | |
| SCHEMBL30535283 | 0.69 | LMNA (0.82) | TDP1LMNACYP11B1CYP11B2CYP19A1 | |
| SCHEMBL676142 | 0.69 | LMNA (0.82) | TDP1LMNACYP11B1CYP11B2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6333341-B1 | TUMOR NECROSIS FACTOR, ANTIINFLAMMATORY AGENTS AND ANALGESICS | AMGEN INC. | 2001-12-25 | — | — | US | disclosed |
| US-6184237-B1 | Substituted pyridine compounds and methods of use | AMGEN INC. | 2001-02-06 | — | — | US | disclosed |