Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | OGG1 | O15527 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | GPR3 | P46089 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7670984 | 0.87 | LOXL2 (0.43) | ESR1LOXL2OGG1ALDH1A1CYP1A2 | |
| SCHEMBL7662066 | 0.84 | LOXL2 (0.41) | LOXL2OGG1ALDH1A1MCL1NPSR1 | |
| SCHEMBL7662062 | 0.84 | MAPT (0.55) | LOXL2ALDH1A1MCL1NPSR1RXFP1 | |
| SCHEMBL7668527 | 0.80 | TRPA1 (0.45) | LOXL2OGG1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7661911 | 0.75 | LOXL2 (0.42) | LOXL2OGG1ALDH1A1CYP1A2MCL1 | |
| SCHEMBL7879489 | 0.74 | TDP1 (0.44) | LOXL2ALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7667320 | 0.73 | LOXL2 (0.43) | LOXL2OGG1ALDH1A1CYP1A2MCL1 | |
| SCHEMBL7674113 | 0.72 | ALOX5 (0.41) | LOXL2OGG1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL7662088 | 0.72 | L3MBTL1 (0.40) | LOXL2ALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7671893 | 0.72 | LOXL2 (0.39) | LOXL2OGG1ALDH1A1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458813-B1 | 2-CYCLOHEXYLOXY-5-(2-CHLOROPHENYLCARBONYLAMINO)PYRIDINE, FOR EXAMPLE; TREATING INFLAMMATION, PAIN, DIABETES, CANCER | AMGEN INC. | 2002-10-01 | — | — | US | disclosed |
| US-6333341-B1 | TUMOR NECROSIS FACTOR, ANTIINFLAMMATORY AGENTS AND ANALGESICS | AMGEN INC. | 2001-12-25 | — | — | US | disclosed |
| US-6184237-B1 | Substituted pyridine compounds and methods of use | AMGEN INC. | 2001-02-06 | — | — | US | disclosed |