SCHEMBL7879775

SCHEMBL7879775

CNC(N)=NC(=O)c1cc2c(Cl)ccc(Oc3ccc(CN)s3)c2[nH]1

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC9A1 P19634 1/20 0.31
LOX P28300 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7881976 0.90 HTR2A (0.32)
SCHEMBL7873799 0.89
SCHEMBL7879632 0.88 SLC9A1 (0.32) SLC9A1
SCHEMBL7873328 0.87 SLC9A1 (0.34) SLC9A1
SCHEMBL7879508 0.87 LMNA (0.32)
SCHEMBL7881268 0.87 MRGPRX4 (0.37) LOX
SCHEMBL7880167 0.84 MTNR1A (0.33) SLC9A1LOX
SCHEMBL7873970 0.84 KDM4E (0.30)
SCHEMBL7885036 0.84 FBP1 (0.34) SLC9A1
SCHEMBL7873551 0.83 SLC9A1 (0.32) SLC9A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6248772-B1 HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS SUMITOMO PHARMACEUTICALS CO., LTD. (JP) 2001-06-19 US disclosed
US-6169107-B1 USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS SUMITOMO PHARMACEUTICAL CO., LTD. (JP) 2001-01-02 US disclosed
EP-0708091-A2 Indoloylguanidine derivatives SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1996-04-24 EP disclosed