SCHEMBL788285

SCHEMBL788285

c1ccc(-c2cccc3c2sc2c(-c4ccc5c(c4)[nH]c4ccccc45)cccc23)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 1/20 0.44
HPGD P15428 1/20 0.44
MAPK1 P28482 1/20 0.44
HTT P42858 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
ALOX5 P09917 1/20 0.43
KIF11 P52732 9/20 0.42
LIMK1 P53667 1/20 0.42
ALDH1A1 P00352 1/20 0.41
GPR3 P46089 1/20 0.41
HSD17B10 Q99714 1/20 0.41
MAPT P10636 1/20 0.39
GABRP O00591 1/20 0.38
GABRD O14764 1/20 0.38
GABRA1 P14867 1/20 0.38
GABRB1 P18505 1/20 0.38
GABRG2 P18507 1/20 0.38
GABRB3 P28472 1/20 0.38
GABRA5 P31644 1/20 0.38
GABRA3 P34903 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL788246 0.97 ALOX5 (0.46) AHRHPGDMAPK1HTTSMN1; SMN2
SCHEMBL457228 0.91 ALOX5 (0.47) AHRHPGDMAPK1HTTSMN1; SMN2
SCHEMBL788806 0.90 ALOX5 (0.46) AHRHPGDMAPK1HTTSMN1; SMN2
SCHEMBL15894714 0.89 ALOX5 (0.46) AHRHPGDMAPK1HTTSMN1; SMN2
SCHEMBL10225913 0.88 ALOX5 (0.49) AHRHPGDMAPK1HTTSMN1; SMN2
SCHEMBL21709354 0.87 KIF11 (0.43) AHRALOX5KIF11ALDH1A1GPR3
SCHEMBL10227383 0.87 ALOX5 (0.44) AHRHPGDMAPK1HTTSMN1; SMN2
SCHEMBL788292 0.87 ALOX5 (0.59) AHRHPGDHTTALOX5KIF11
SCHEMBL30959738 0.87 ALOX5 (0.59) AHRHPGDHTTALOX5KIF11
SCHEMBL26047394 0.87 ALOX5 (0.47) AHRHPGDMAPK1HTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9450188-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-09-20 US disclosed
US-20140145175-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-05-29 US disclosed
US-8642782-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-02-04 US disclosed
US-20120071668-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-03-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120071668-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SLC39A3, SULT1A1, NUTF2 AHR 71/4885HPGD 1834/4885MAPK1 3361/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.