Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 4/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.41 |
| ▸ | PRKAG3 | Q9UGI9 | 4/20 | 0.41 |
| ▸ | PRKAG2 | Q9UGJ0 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | KDR | P35968 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | FLT1 | P17948 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10234784 | 0.91 | SIGMAR1 (0.43) | SIGMAR1PRKAB1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL7884476 | 0.91 | SIGMAR1 (0.41) | SIGMAR1PRKAB1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL7881302 | 0.86 | PRKAB1 (0.43) | SIGMAR1HSP90AA1PRKAB1PRKAB2PRKAG1 | |
| SCHEMBL584148 | 0.82 | AKR1C3 (0.43) | HSP90AA1KDM4EKDRALDH1A1NPC1 | |
| SCHEMBL10234783 | 0.77 | ACHE (0.42) | PRKAB1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL7882569 | 0.76 | PRKAB2 (0.41) | PRKAB1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL2703163 | 0.74 | JAK1 (0.40) | HSP90AA1KDRALDH1A1NPC1RAB9A | |
| SCHEMBL10328032 | 0.74 | HSP90AA1 (0.39) | HSP90AA1KDRLCKSRC | |
| SCHEMBL596083 | 0.74 | CHEK1 (0.44) | HSP90AA1KDM4EALDH1A1HPGDGAA | |
| SCHEMBL6893608 | 0.73 | MAP4K4 (0.38) | KDRNPC1MEN1KMT2ALCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MTOR, RICTOR, RPTOR | SIGMAR1 4058/4885HSP90AA1 617/4885PRKAB1 84/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.