Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 19/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.59 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.56 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7876342 | 0.84 | HTR1A (0.61) | HTR1ASLC6A4ADRB2ADRB1ADRB3 | |
| SCHEMBL9181615 | 0.81 | ABCB1 (0.59) | HTR1AADRB2ADRB1ADRB3 | |
| SCHEMBL7876541 | 0.81 | HTR1A (0.72) | HTR1ASLC6A4 | |
| SCHEMBL7887628 | 0.81 | HTR1A (0.74) | HTR1ASLC6A4 | |
| SCHEMBL7882931 | 0.81 | HTR1A (0.70) | HTR1ASLC6A4 | |
| SCHEMBL7876327 | 0.80 | DRD2 (0.74) | HTR1ASLC6A4ADRB2ADRB1ADRB3 | |
| SCHEMBL7885674 | 0.79 | DRD4 (0.73) | HTR1ASLC6A4ADRB2ADRB1ADRB3 | |
| SCHEMBL7884088 | 0.79 | HTR1A (0.63) | HTR1ASLC6A4ADRB2ADRB1ADRB3 | |
| Mindodilol SCHEMBL2107921 | 0.78 | ADRB2 (0.63) | HTR1ASLC6A4ADRB2ADRB1ADRB3 | |
| Mindodilol SCHEMBL11540170 | 0.78 | ADRB2 (0.63) | HTR1ASLC6A4ADRB2ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172073-B1 | BENZIMIDAZOLYLOXY ALKANAMINES AS SEROTONIN REUPTAKE INHIBITORS; NICOTINE AND TOBACCO WITHDRAWAL; PSYCHOLOGICAL, EATING, BRAIN, GASTROINTESTINAL, SLEEP, AND SEXUAL DISORDERS | ELI LILLY AND COMPANY | 2001-01-09 | — | — | US | disclosed |
| US-5627196-A | ANTIDEPRESSANTS AND ANTISEROTONIN AGENTS | ELI LILLY AND COMPANY (US) | 1997-05-06 | — | — | US | disclosed |
| US-5614523-A | INDOLYLOXY COMPOUNDS | ELI LILLY AND COMPANY (US) | 1997-03-25 | — | — | US | disclosed |
| US-5576321-A | ALKOXY-SUBSTITUTED INDOLES | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| EP-0722941-A2 | Compounds having effects on serotonin-related systems | ELI LILLY AND COMPANY (US) | 1996-07-24 | — | — | EP | disclosed |