Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.53 |
| ▸ | CTSS | P25774 | 3/20 | 0.53 |
| ▸ | CASP3 | P42574 | 2/20 | 0.51 |
| ▸ | CASP1 | P29466 | 5/20 | 0.46 |
| ▸ | REN | P00797 | 1/20 | 0.44 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 3/20 | 0.42 |
| ▸ | CTSL | P07711 | 3/20 | 0.42 |
| ▸ | NMBR | P28336 | 2/20 | 0.42 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.42 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.42 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.42 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9962153 | 0.90 | CASP3 (0.59) | CTSKCTSSCASP3CASP1REN | |
| SCHEMBL9961959 | 0.83 | CASP3 (0.62) | CTSKCTSSCASP3CASP1REN | |
| SCHEMBL7888622 | 0.82 | CASP3 (0.53) | CTSKCTSSCASP3CASP1REN | |
| SCHEMBL29358005 | 0.81 | CASP3 (0.50) | CTSKCTSSCASP3CASP1REN | |
| SCHEMBL19944839 | 0.80 | NMBR (0.59) | CTSKCTSSCASP3CASP1REN | |
| SCHEMBL9962288 | 0.80 | CASP3 (0.60) | CTSKCASP3CASP1RENCTSB | |
| SCHEMBL19015914 | 0.80 | CASP3 (0.52) | CTSKCTSSCASP3CASP1TGM2 | |
| SCHEMBL7888466 | 0.80 | CASP3 (0.52) | CTSKCTSSCASP3CASP1TGM2 | |
| SCHEMBL7877903 | 0.79 | CTSL (0.46) | CTSKCTSSCASP3CASP1MAPT | |
| SCHEMBL19606065 | 0.78 | CASP1 (0.58) | CTSKCTSSCASP3CASP1REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010133000-A1 | SELECTIVE CASPASE INHIBITORS AND USES THEREOF | NEW WORLD LABORATORIES INC. (CA) | 2010-11-25 | — | — | WO | disclosed |