Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 7/20 | 0.78 |
| ▸ | TRPC6 | Q9Y210 | 7/20 | 0.78 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.69 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | ATM | Q13315 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | GRM5 | P41594 | 1/20 | 0.55 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL789873 | 0.87 | TRPC3 (0.81) | TRPC3TRPC6L3MBTL1MDM2GAA | |
| SCHEMBL789016 | 0.82 | TRPC3 (1.00) | TRPC3TRPC6L3MBTL1MDM2GAA | |
| SCHEMBL10087858 | 0.80 | TRPC3 (0.58) | TRPC3TRPC6L3MBTL1MDM2GAA | |
| SCHEMBL27827048 | 0.80 | AMY1A (0.67) | TRPC3TRPC6L3MBTL1MDM2GAA | |
| SCHEMBL525597 | 0.80 | CSNK2A1 (0.65) | TRPC3TRPC6L3MBTL1MDM2GAA | |
| SCHEMBL806827 | 0.78 | GAA (0.78) | TRPC3TRPC6L3MBTL1MDM2GAA | |
| SCHEMBL14317600 | 0.78 | ATP4A (0.55) | TRPC3TRPC6GAAMAPK1KMT2A | |
| SCHEMBL789091 | 0.76 | TRPC3 (0.78) | TRPC3TRPC6L3MBTL1MDM2GAA | |
| SCHEMBL790315 | 0.75 | MAPT (0.64) | TRPC3TRPC6GAAMAPK1KMT2A | |
| SCHEMBL789564 | 0.74 | TRPC3 (1.00) | TRPC3TRPC6L3MBTL1MDM2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037351-A1 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | claimed |
| WO-2012037351-A1 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |