Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.78 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.78 |
| ▸ | ATM | Q13315 | 1/20 | 0.78 |
| ▸ | TRPC3 | Q13507 | 7/20 | 0.78 |
| ▸ | TRPC6 | Q9Y210 | 7/20 | 0.78 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.78 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.78 |
| ▸ | AMY1A | P0DUB6 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL789016 | 0.88 | TRPC3 (1.00) | GAAMAPK1ATMTRPC3TRPC6 | |
| SCHEMBL788828 | 0.78 | TRPC3 (0.78) | GAAMAPK1ATMTRPC3TRPC6 | |
| SCHEMBL10080529 | 0.74 | TRPC3 (0.58) | GAAMAPK1ATMTRPC3TRPC6 | |
| SCHEMBL27827048 | 0.73 | AMY1A (0.67) | GAATRPC3TRPC6MDM2L3MBTL1 | |
| SCHEMBL525597 | 0.71 | CSNK2A1 (0.65) | GAATRPC3TRPC6MDM2L3MBTL1 | |
| SCHEMBL807013 | 0.70 | TRPC3 (1.00) | GAAMAPK1ATMTRPC3TRPC6 | |
| SCHEMBL798510 | 0.69 | TRPC3 (0.67) | GAAMAPK1ATMTRPC3TRPC6 | |
| SCHEMBL5524312 | 0.67 | CA1 (0.72) | MAPK1MAPT | |
| SCHEMBL31565935 | 0.67 | SCN9A (0.47) | GAAMAPK1ATMTRPC3TRPC6 | |
| SCHEMBL806828 | 0.67 | TRPC3 (0.64) | GAAMAPK1ATMTRPC3TRPC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037349-A2 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |