Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.40 |
| ▸ | SLC9A3 | P48764 | 3/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 7/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2597110 | 0.99 | GPR119 (0.40) | GPR119SLC9A3PTGS2BRD4CYP2C9 | |
| Hydrochloric Acid SCHEMBL14917661 | 0.90 | BRD4 (0.35) | GPR119BRD4HTR2C | |
| Hydrochloric Acid SCHEMBL789439 | 0.86 | SLC9A3 (0.32) | SLC9A3 | |
| SCHEMBL788886 | 0.85 | SCN9A (0.34) | HTR2C | |
| SCHEMBL790469 | 0.85 | SCN9A (0.34) | HTR2C | |
| SCHEMBL789216 | 0.80 | SLC6A9 (0.34) | GPR119BRD4SLC6A9 | |
| Hydrochloric Acid SCHEMBL2597053 | 0.77 | TSHR (0.31) | — | |
| SCHEMBL2597109 | 0.76 | SLC6A9 (0.37) | GPR119BRD4SLC6A9 | |
| SCHEMBL789299 | 0.76 | DPP4 (0.30) | — | |
| SCHEMBL14795126 | 0.76 | GPR119 (0.38) | GPR119SLC9A3PTGS2BRD4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616074-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | Array Biopharma, Inc. (US) | 2013-07-24 | — | — | EP | disclosed |
| WO-2013066869-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2013-05-10 | — | — | WO | disclosed |
| WO-2012037393-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2012-03-22 | — | — | WO | disclosed |