SCHEMBL7895374

SCHEMBL7895374

Cc1cccc(C)c1CNc1c(NCC(F)(F)C(F)(F)F)c(=O)c1=O

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
CYP3A4 P08684 10/20 0.34
CHEK2 O96017 3/20 0.34
PRKACA P17612 3/20 0.34
RPS6KB1 P23443 3/20 0.34
GSK3A P49840 3/20 0.34
GSK3B P49841 3/20 0.34
RPS6KA3 P51812 3/20 0.34
ROCK1 Q13464 3/20 0.34
PRKG1 Q13976 3/20 0.34
PKN2 Q16513 3/20 0.34
CDC42BPA Q5VT25 3/20 0.34
HIPK4 Q8NE63 3/20 0.34
AURKB Q96GD4 3/20 0.34
CSNK1G3 Q9Y6M4 3/20 0.34
ROCK2 O75116 2/20 0.34
AKT1 P31749 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7894010 0.77 HDAC1 (0.38) HDAC3HDAC1HDAC2HDAC6CYP3A4
SCHEMBL7896944 0.77 L3MBTL1 (0.34)
SCHEMBL7597337 0.77 ALDH1A1 (0.42) P2RX7
SCHEMBL7895653 0.73 PLK1 (0.37) HDAC3HDAC1HDAC2HDAC6CYP3A4
SCHEMBL7886982 0.72 PLK1 (0.51) HDAC3HDAC1HDAC2HDAC6CHEK2
SCHEMBL7896821 0.69 GAA (0.47) HDAC3HDAC1HDAC2HDAC6CYP3A4
SCHEMBL7886455 0.69 CYP3A4 (0.45) HDAC3HDAC1HDAC2HDAC6CYP3A4
SCHEMBL7895056 0.69 CYP3A4 (0.41) HDAC3HDAC1HDAC2HDAC6CYP3A4
SCHEMBL18235954 0.67 MAPT (0.55) PDK1PDK2PDK3PDK4
SCHEMBL7895105 0.66 CYP3A4 (0.42) CYP3A4CD38ABL1P2RX7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1151990-A1 Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones AMERICAN HOME PRODUCTS CORPORATION (US) 2001-11-07 EP claimed
EP-0934257-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1999-08-11 EP claimed
US-5780505-A ADMINISTERING AS SMOOTH MUSCLE RELAXANT AMERICAN HOME PRODUCTS CORPORATION (US) 1998-07-14 US claimed
WO-1998002413-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1998-01-22 WO claimed
EP-1151990-A1 Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones AMERICAN HOME PRODUCTS CORPORATION (US) 2001-11-07 EP disclosed
EP-0934257-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1999-08-11 EP disclosed
US-5780505-A ADMINISTERING AS SMOOTH MUSCLE RELAXANT AMERICAN HOME PRODUCTS CORPORATION (US) 1998-07-14 US disclosed
WO-1998002413-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1998-01-22 WO disclosed