Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | MARK3 | P27448 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | FRK | P42685 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11548569 | 0.78 | IKBKB (0.63) | CDC7PLK4MAPK13DAPK3DYRK3 | |
| SCHEMBL30564933 | 0.76 | ALDH1A1 (0.56) | CDC7PLK4MAPK13DAPK3DYRK3 | |
| SCHEMBL910922 | 0.76 | ALDH1A1 (0.56) | CDC7PLK4MAPK13DAPK3DYRK3 | |
| SCHEMBL807329 | 0.72 | SCN10A (0.48) | CHEK2PRNPMAP4K4MEN1KMT2A | |
| SCHEMBL18227141 | 0.72 | BACE1 (0.46) | PRNPGRM2MAP4K4MEN1KMT2A | |
| SCHEMBL790083 | 0.71 | PTGS2 (0.51) | IKBKBCHUKMEN1KMT2A | |
| SCHEMBL790264 | 0.69 | PRNP (0.53) | MAPTIKBKBPRNPCASP1DHODH | |
| SCHEMBL790542 | 0.69 | SRC (0.49) | CHEK2MAPTCASP1MEN1KMT2A | |
| SCHEMBL807327 | 0.69 | HPGD (0.53) | GRM2CNR1ALDH1A1 | |
| SCHEMBL15928349 | 0.69 | ALOX5AP (0.43) | MKNK2IKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |