Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | SLC25A5 | P05141 | 1/20 | 0.31 |
| ▸ | PTGES | O14684 | 2/20 | 0.30 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | DLAT | P10515 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.30 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29957759 | 0.70 | KDM4E (0.32) | KDM4EMEN1AKR1B10ALOX5KMT2A | |
| SCHEMBL7896033 | 0.66 | ALOX5 (0.36) | KDM4EMEN1AKR1B10ALOX5KMT2A | |
| SCHEMBL13649105 | 0.64 | SLC25A5 (0.35) | KDM4EMEN1AKR1B10ALOX5KMT2A | |
| SCHEMBL2439244 | 0.60 | ALOX5 (0.37) | KDM4EMEN1AKR1B10ALOX5KMT2A | |
| SCHEMBL29351523 | 0.59 | ALOX5 (0.61) | KDM4EMEN1AKR1B10ALOX5KMT2A | |
| SCHEMBL2441401 | 0.58 | ALOX5 (0.35) | KDM4EMEN1AKR1B10ALOX5KMT2A | |
| SCHEMBL12729608 | 0.57 | SLC25A5 (0.37) | SLC25A5 | |
| SCHEMBL20634111 | 0.57 | SLC25A5 (0.46) | KDM4ESLC25A5MAPTSMN1; SMN2 | |
| SCHEMBL31576804 | 0.57 | ALOX5 (0.51) | KDM4EMEN1AKR1B10ALOX5KMT2A | |
| SCHEMBL1573209 | 0.55 | SLC25A5 (0.47) | KDM4EALOX5SLC25A5PTGESMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6177474-B1 | AROMATIC COMPOUND CONTAINING KETONE AND HYDROXY GROUPS | HOECHST MARION ROUSSEL (FR) | 2001-01-23 | — | — | US | disclosed |
| EP-0994093-A1 | POLYHYDROXYPHENOL DERIVATIVES AND PREVENTIVE AND THERAPEUTIC AGENTS FOR BONE AND CARTILAGE DISEASES CONTAINING THE SAME | Hoechst Marion Roussel, Ltd. (JP) | 2000-04-19 | — | — | EP | disclosed |