Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 9/20 | 0.59 |
| ▸ | ME3 | Q16798 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | ME2 | P23368 | 1/20 | 0.48 |
| ▸ | ME1 | P48163 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7899005 | 0.96 | ME3 (0.60) | GRIN2BME3NPC1ALDH1A1GAA | |
| SCHEMBL7897978 | 0.91 | ME3 (0.62) | GRIN2BME3NPC1ALDH1A1GAA | |
| SCHEMBL7898015 | 0.85 | KDM4E (0.54) | GRIN2BSMN1; SMN2GRIN1SIGMAR1 | |
| SCHEMBL7844261 | 0.81 | VCP (0.60) | GRIN2BME3MAPTGRIN1SIGMAR1 | |
| SCHEMBL7899612 | 0.80 | GRIN2B (0.61) | GRIN2BGAAMAPTGRIN1SIGMAR1 | |
| SCHEMBL5690253 | 0.79 | GRIN2B (0.62) | GRIN2BGRIN1SIGMAR1 | |
| SCHEMBL5689782 | 0.79 | GRIN2B (0.62) | GRIN2BGRIN1SIGMAR1 | |
| SCHEMBL5689779 | 0.79 | GRIN2B (0.62) | GRIN2BGRIN1SIGMAR1 | |
| SCHEMBL25006478 | 0.79 | GRIN2B (0.78) | GRIN2BGRIN1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7900985 | 0.78 | GRIN2B (0.60) | GRIN2BGRIN1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184236-B1 | Method of treating a neurodegenerative disease by administering an aryl-cyclohexylamine derivative | HOFFMANN-LA ROCHE INC. | 2001-02-06 | — | — | US | disclosed |
| EP-0982026-A2 | Use of aryl-cyclohexylamine derivatives in the manufacture of NMDA receptor blockers | F. HOFFMANN-LA ROCHE AG (CH) | 2000-03-01 | — | — | EP | disclosed |