SCHEMBL7899050

SCHEMBL7899050

COc1ccc(N=Nc2c(S(=O)(=O)OC(C)C)cc3cc(N)ccc3c2O)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRMT1 Q99873 3/20 0.48
CARM1 Q86X55 1/20 0.48
PHLPP2 Q6ZVD8 2/20 0.45
CDK1 P06493 2/20 0.41
CDK2 P24941 2/20 0.41
ENPP2 Q13822 7/20 0.40
PTGS2 P35354 1/20 0.38
PRMT3 O60678 1/20 0.38
EP300 Q09472 1/20 0.38
PRMT6 Q96LA8 1/20 0.38
MAPT P10636 2/20 0.37
RAB9A P51151 2/20 0.37
MEN1 O00255 1/20 0.37
NPC1 O15118 1/20 0.37
KMT2A Q03164 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
CA2 P00918 1/20 0.37
CA3 P07451 1/20 0.37
CD40 P25942 1/20 0.35
CD40LG P29965 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7899064 0.86 PHLPP2 (0.58) PRMT1CARM1PHLPP2ENPP2PRMT3
SCHEMBL7899061 0.86 PHLPP2 (0.58) PRMT1CARM1PHLPP2ENPP2PRMT3
SCHEMBL7907855 0.81 PRMT1 (0.53) PRMT1CARM1PHLPP2ENPP2PRMT3
SCHEMBL7906632 0.81 PRMT1 (0.53) PRMT1CARM1PHLPP2ENPP2PRMT3
SCHEMBL7906467 0.80 PRMT1 (0.77) PRMT1CARM1PHLPP2ENPP2PRMT3
SCHEMBL7899048 0.79 PRMT1 (0.51) PRMT1CARM1PHLPP2ENPP2PRMT3
SCHEMBL29702399 0.75 ENPP2 (0.58) PRMT1PHLPP2ENPP2PRMT3EP300
SCHEMBL7770984 0.75 PHLPP2 (0.62) PRMT1CARM1PHLPP2ENPP2MAPT
SCHEMBL8059751 0.75 PHLPP2 (0.62) PRMT1CARM1PHLPP2ENPP2MAPT
SCHEMBL29702431 0.74 ENPP2 (0.59) PRMT1PHLPP2CDK1CDK2ENPP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6200963-B1 USEFUL AS FEMALE AND MALE CONTRACEPTIVE AGENTS AMERICAN HOME PRODUCTS CORPORATION 2001-03-13 US claimed
WO-2000058276-A1 7-AMINO-4-HYDROXY-3-(4-METHOXY-PHENYLAZO)-NAPHTHALENE-2-SULFONIC ACID DERIVATIVES AS FSH ANTAGONISTS AMERICAN HOME PRODUCTS CORPORATION (US) 2000-10-05 WO claimed
US-6200963-B1 USEFUL AS FEMALE AND MALE CONTRACEPTIVE AGENTS AMERICAN HOME PRODUCTS CORPORATION 2001-03-13 US disclosed
WO-2000058276-A1 7-AMINO-4-HYDROXY-3-(4-METHOXY-PHENYLAZO)-NAPHTHALENE-2-SULFONIC ACID DERIVATIVES AS FSH ANTAGONISTS AMERICAN HOME PRODUCTS CORPORATION (US) 2000-10-05 WO disclosed