SCHEMBL7907855

SCHEMBL7907855

COc1ccc(N=Nc2c(S(=O)(=O)OC(C)C)cc3cc(NC(=O)c4ccccc4)ccc3c2O)cc1

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PRMT1 Q99873 3/20 0.53
PRMT3 O60678 1/20 0.53
EP300 Q09472 1/20 0.53
PRMT6 Q96LA8 1/20 0.53
CARM1 Q86X55 1/20 0.53
ENPP2 Q13822 9/20 0.51
NPC1 O15118 3/20 0.47
RAB9A P51151 3/20 0.47
KCNK9 Q9NPC2 1/20 0.46
PHLPP2 Q6ZVD8 1/20 0.46
CD40 P25942 1/20 0.44
CD40LG P29965 1/20 0.44
CCR8 P51685 1/20 0.42
NLRP3 Q96P20 1/20 0.42
HDAC1 Q13547 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7906632 0.93 PRMT1 (0.53) PRMT1PRMT3EP300PRMT6CARM1
SCHEMBL7906557 0.89 PRMT1 (0.66) PRMT1PRMT3EP300PRMT6CARM1
SCHEMBL7906615 0.89 PRMT1 (0.66) PRMT1PRMT3EP300PRMT6CARM1
SCHEMBL7899048 0.89 PRMT1 (0.51) PRMT1PRMT3EP300PRMT6CARM1
SCHEMBL7905266 0.82 PRMT1 (0.58) PRMT1PRMT3EP300PRMT6CARM1
SCHEMBL7905259 0.82 PRMT1 (0.58) PRMT1PRMT3EP300PRMT6CARM1
SCHEMBL7899050 0.81 PRMT1 (0.48) PRMT1PRMT3EP300PRMT6CARM1
SCHEMBL7906467 0.81 PRMT1 (0.77) PRMT1PRMT3EP300PRMT6CARM1
SCHEMBL17540333 0.80 PRMT3 (0.74) PRMT1PRMT3EP300PRMT6ENPP2
SCHEMBL27913238 0.79 ENPP2 (0.62) PRMT1PRMT3EP300PRMT6CARM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6200963-B1 USEFUL AS FEMALE AND MALE CONTRACEPTIVE AGENTS AMERICAN HOME PRODUCTS CORPORATION 2001-03-13 US claimed
WO-2000058276-A1 7-AMINO-4-HYDROXY-3-(4-METHOXY-PHENYLAZO)-NAPHTHALENE-2-SULFONIC ACID DERIVATIVES AS FSH ANTAGONISTS AMERICAN HOME PRODUCTS CORPORATION (US) 2000-10-05 WO claimed
US-6200963-B1 USEFUL AS FEMALE AND MALE CONTRACEPTIVE AGENTS AMERICAN HOME PRODUCTS CORPORATION 2001-03-13 US disclosed
WO-2000058276-A1 7-AMINO-4-HYDROXY-3-(4-METHOXY-PHENYLAZO)-NAPHTHALENE-2-SULFONIC ACID DERIVATIVES AS FSH ANTAGONISTS AMERICAN HOME PRODUCTS CORPORATION (US) 2000-10-05 WO disclosed