Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.52 |
| ▸ | HTR3B | O95264 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 1/20 | 0.52 |
| ▸ | HTR3A | P46098 | 1/20 | 0.52 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.52 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 5/20 | 0.42 |
| ▸ | NOS3 | P29474 | 3/20 | 0.42 |
| ▸ | KIF11 | P52732 | 6/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.41 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.41 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.41 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NOS2 | P35228 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenol SCHEMBL29220711 | 0.84 | KIF11 (0.48) | HTR3EHTR3BPLAUHTR3AHTR3D | |
| SCHEMBL18400206 | 0.80 | ESR1 (0.50) | HTR3EHTR3BPLAUHTR3AHTR3D | |
| SCHEMBL3185610 | 0.78 | HTR3E (0.56) | HTR3EHTR3BPLAUHTR3AHTR3D | |
| SCHEMBL30102082 | 0.78 | HTR3E (0.56) | HTR3EHTR3BPLAUHTR3AHTR3D | |
| SCHEMBL17918860 | 0.78 | HTR3E (0.56) | HTR3EHTR3BPLAUHTR3AHTR3D | |
| SCHEMBL19707397 | 0.77 | HTR3E (0.50) | HTR3EHTR3BPLAUHTR3AHTR3D | |
| SCHEMBL18399382 | 0.77 | SLC22A2 (0.32) | HTR3EHTR3BPLAUHTR3AHTR3D | |
| SCHEMBL63468 | 0.76 | ALDH1A1 (0.67) | HTR3EHTR3BPLAUHTR3AHTR3D | |
| SCHEMBL1547498 | 0.74 | HTR3E (0.52) | HTR3EHTR3BPLAUHTR3AHTR3D | |
| SCHEMBL14395758 | 0.74 | HTR3E (0.52) | HTR3EHTR3BPLAUHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117777127-A | Chiral tetrahydro-beta-carboline derivative and preparation method and application thereof | 中山大学 | 2024-03-29 | — | — | CN | disclosed |
| US-20230242699-A1 | POLYCARBAMATE SYNTHESIS VIA CHAIN-GROWTH COPOLYMERIZATION | FENG, Xiaoshuang (CN) | 2023-08-03 | — | — | US | disclosed |
| EP-2870143-B1 | TRIAZOLE COMPOUNDS AS ANTIVIRALS | HOFFMANN LA ROCHE (CH) | 2017-05-17 | — | — | EP | disclosed |
| WO-2010062559-A1 | SUBSTITUTED PYRAZOLOQUINOLINES AND DERIVATIVES THEREOF | SCHERING CORPORATION (US) | 2010-06-03 | — | — | WO | disclosed |
| US-20070060582-A1 | 1,4-Disubstituted isoquinilone derivatives as raf-kinase inhibitors useful for the treatment of proliferative diseases | FINK CYNTHIA A | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060582-A1 | 1,4-Disubstituted isoquinilone derivatives as raf-kinase inhibitors useful for the treatment of proliferative diseases | BRAF, RAF1, NRAS | HTR3E 2179/4885HTR3B 2528/4885PLAU 4863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.