Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.56 |
| ▸ | ACACB | O00763 | 2/20 | 0.55 |
| ▸ | ME3 | Q16798 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | RORC | P51449 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CKS1B | P61024 | 1/20 | 0.47 |
| ▸ | SKP1 | P63208 | 1/20 | 0.47 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20887692 | 0.90 | ACACB (0.61) | LTA4HACACBME3MAPTKDM4E | |
| SCHEMBL20887689 | 0.90 | ACACB (0.61) | LTA4HACACBME3MAPTKDM4E | |
| SCHEMBL7898002 | 0.85 | ME3 (0.76) | ME3MAPTALDH1A1LMNAHTT | |
| SCHEMBL20887739 | 0.85 | MAOB (0.54) | LTA4HACACBMAPTKDM4EALDH1A1 | |
| SCHEMBL12321963 | 0.83 | CKS1B (0.53) | ACACBME3MAPTKDM4EALDH1A1 | |
| SCHEMBL2883836 | 0.81 | DRD2 (0.53) | LTA4HME3MAPTKDM4ERORC | |
| SCHEMBL7899165 | 0.81 | ME3 (0.58) | LTA4HME3MAPTALDH1A1LMNA | |
| SCHEMBL19658840 | 0.79 | DRD2 (0.65) | LTA4HME3RORCDRD2DRD3 | |
| SCHEMBL17888549 | 0.77 | RAB9A (0.68) | LTA4HACACBMAPTKDM4EALDH1A1 | |
| SCHEMBL32665123 | 0.77 | ACACB (0.52) | ACACBME3SLC6A5CKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1141936-C | Usage of aryl-cyclohexylamine derivant in anti-disturbance of central nervous system | - | 2004-03-17 | — | — | CN | disclosed |
| US-6184236-B1 | Method of treating a neurodegenerative disease by administering an aryl-cyclohexylamine derivative | HOFFMANN-LA ROCHE INC. | 2001-02-06 | — | — | US | disclosed |
| CN-1248439-A | Usage of aryl-cyclohexylamine derivant in anti-disturbance of central nervous system | HOFFMAN LA ROCHE & CO AKTEINGE (DE) | 2000-03-29 | — | — | CN | disclosed |
| EP-0982026-A2 | Use of aryl-cyclohexylamine derivatives in the manufacture of NMDA receptor blockers | F. HOFFMANN-LA ROCHE AG (CH) | 2000-03-01 | — | — | EP | disclosed |