Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.36 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7527637 | 1.00 | GRM5 (0.46) | GRM5CYP2D6CA2EPHX1EDNRA | |
| SCHEMBL7899177 | 0.86 | CYP2C9 (0.43) | GRM5CYP2D6HSPA1APTPN7TDP1 | |
| SCHEMBL7534121 | 0.85 | GRM5 (0.44) | GRM5CYP2D6CA2EPHX1KDM4E | |
| SCHEMBL11546959 | 0.85 | CYP2D6 (0.46) | GRM5CYP2D6CA2EPHX1TDP1 | |
| SCHEMBL6509232 | 0.82 | EDNRA (0.47) | GRM5CYP2D6EDNRAHSPA1APTPN7 | |
| SCHEMBL8380944 | 0.81 | EPHX1 (0.37) | GRM5CYP2D6CA2EPHX1EDNRA | |
| SCHEMBL4681142 | 0.81 | CYP2D6 (0.59) | GRM5CYP2D6TDP1POLBALDH1A1 | |
| SCHEMBL18012037 | 0.81 | CYP2D6 (0.59) | GRM5CYP2D6TDP1POLBALDH1A1 | |
| SCHEMBL11430937 | 0.77 | ALDH1A1 (0.47) | KDM4EMAPTALDH1A1 | |
| SCHEMBL9212615 | 0.76 | KDM4E (0.41) | KDM4EPOLBMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5356918-A | Oxazolidinone compounds and method of using the same as a vasodilator | SANKYO COMPANY, LTD. (JP) | 1994-10-18 | — | — | US | disclosed |
| US-5298516-A | Treatment of cardiovascular disorders, angina | SANKYO COMPANY, LIMITED (JP) | 1994-03-29 | — | — | US | disclosed |