Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 4/20 | 0.60 |
| ▸ | RXRA | P19793 | 10/20 | 0.52 |
| ▸ | RARB | P10826 | 9/20 | 0.52 |
| ▸ | RARG | P13631 | 9/20 | 0.52 |
| ▸ | RXRB | P28702 | 8/20 | 0.52 |
| ▸ | RXRG | P48443 | 6/20 | 0.52 |
| ▸ | RARA | P10276 | 8/20 | 0.49 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | P4HB | P07237 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7899451 | 1.00 | CYP26A1 (0.60) | CYP26A1RXRARARBRARGRXRB | |
| SCHEMBL29567021 | 0.89 | CYP26A1 (0.75) | CYP26A1RXRARARBRARGRXRB | |
| SCHEMBL17914357 | 0.89 | CYP26A1 (0.75) | CYP26A1RXRARARBRARGRXRB | |
| SCHEMBL7900823 | 0.88 | RXRA (0.53) | CYP26A1RXRARARBRARGRXRB | |
| SCHEMBL7900821 | 0.88 | RXRA (0.53) | CYP26A1RXRARARBRARGRXRB | |
| SCHEMBL7758836 | 0.87 | CYP26A1 (0.79) | CYP26A1RXRARARBRARGRXRB | |
| SCHEMBL7758834 | 0.87 | CYP26A1 (0.79) | CYP26A1RXRARARBRARGRXRB | |
| SCHEMBL7872206 | 0.84 | RARA (0.55) | CYP26A1RXRARARBRARGRXRB | |
| SCHEMBL7872209 | 0.84 | RARA (0.55) | CYP26A1RXRARARBRARGRXRB | |
| SCHEMBL3108598 | 0.80 | BCHE (0.54) | KDM4EMEN1KMT2AGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258775-B1 | 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-07-10 | — | — | US | disclosed |