Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26B1 | Q9NR63 | 4/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.46 |
| ▸ | RXRA | P19793 | 6/20 | 0.45 |
| ▸ | RXRG | P48443 | 4/20 | 0.45 |
| ▸ | RXRB | P28702 | 3/20 | 0.45 |
| ▸ | RARA | P10276 | 4/20 | 0.45 |
| ▸ | RARB | P10826 | 4/20 | 0.45 |
| ▸ | RARG | P13631 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8529268 | 0.83 | RXRA (0.58) | CYP26B1CYP26A1RXRARXRGRXRB | |
| SCHEMBL7897276 | 0.81 | RXRA (0.43) | RXRARXRGRXRBRARBRARG | |
| SCHEMBL8424521 | 0.78 | MAPT (0.48) | MAPTCYP3A4TTRDPP4 | |
| SCHEMBL8424519 | 0.78 | MAPT (0.48) | MAPTCYP3A4TTRDPP4 | |
| SCHEMBL18786579 | 0.78 | RXRA (0.52) | CYP26B1CYP26A1RXRARXRGRXRB | |
| SCHEMBL18214356 | 0.78 | MAPT (0.43) | RXRARXRGRXRBMAPTCYP3A4 | |
| SCHEMBL18214437 | 0.78 | MAPT (0.43) | RXRARXRGRXRBMAPTCYP3A4 | |
| SCHEMBL7882982 | 0.77 | TTR (0.58) | CYP26B1CYP26A1RXRARARARARB | |
| SCHEMBL7882979 | 0.77 | TTR (0.58) | CYP26B1CYP26A1RXRARARARARB | |
| SCHEMBL16831438 | 0.76 | GPR52 (0.54) | MAPTCYP3A4TTRDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258775-B1 | 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-07-10 | — | — | US | disclosed |