Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 15/20 | 0.62 |
| ▸ | RXRG | P48443 | 8/20 | 0.62 |
| ▸ | RXRB | P28702 | 7/20 | 0.62 |
| ▸ | RARG | P13631 | 6/20 | 0.62 |
| ▸ | RARB | P10826 | 5/20 | 0.62 |
| ▸ | RARA | P10276 | 4/20 | 0.45 |
| ▸ | CYP26B1 | Q9NR63 | 5/20 | 0.43 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | HNF4A | P41235 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7882979 | 0.79 | TTR (0.58) | RXRARARGRARBRARACYP26B1 | |
| SCHEMBL7882982 | 0.79 | TTR (0.58) | RXRARARGRARBRARACYP26B1 | |
| SCHEMBL7760210 | 0.77 | BACE1 (0.54) | RXRARXRGRXRBRARGRARB | |
| SCHEMBL7759711 | 0.77 | RXRA (0.46) | RXRARXRGRXRBRARGRARB | |
| SCHEMBL7759726 | 0.77 | BACE1 (0.54) | RXRARXRGRXRBRARGRARB | |
| SCHEMBL7761537 | 0.77 | RXRA (0.46) | RXRARXRGRXRBRARGRARB | |
| SCHEMBL14437922 | 0.77 | RXRA (1.00) | RXRARXRGRXRBRARGRARB | |
| SCHEMBL8486156 | 0.76 | L3MBTL1 (0.52) | — | |
| SCHEMBL8486160 | 0.76 | L3MBTL1 (0.52) | — | |
| SCHEMBL7899456 | 0.75 | CYP26B1 (0.46) | RXRARXRGRXRBRARGRARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258775-B1 | 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-07-10 | — | — | US | disclosed |