Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 8/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 8/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 6/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7898968 | 0.89 | CHRNB2 (0.46) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| SCHEMBL7891157 | 0.74 | KDM4E (0.35) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| SCHEMBL7898965 | 0.73 | MEN1 (0.46) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| SCHEMBL7892958 | 0.73 | CHRNB2 (0.45) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| SCHEMBL156842 | 0.68 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| SCHEMBL7901471 | 0.65 | CHRNB2 (0.45) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| SCHEMBL7901769 | 0.65 | MEN1 (0.46) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| SCHEMBL7898928 | 0.64 | KDM4E (0.38) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| SCHEMBL27467551 | 0.63 | — | — | |
| SCHEMBL7900671 | 0.63 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |