Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 2/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 2/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7900511 | 1.00 | ALOX12 (0.48) | ALOX12HRH4HRH3NAAAIMPDH2 | |
| SCHEMBL7681578 | 0.82 | CYP3A4 (0.42) | HRH4IMPDH2KDM4E | |
| SCHEMBL7681587 | 0.82 | CYP3A4 (0.42) | HRH4IMPDH2KDM4E | |
| SCHEMBL7902073 | 0.79 | NAAA (0.48) | ALOX12HRH4HRH3NAAAIMPDH2 | |
| SCHEMBL7900339 | 0.79 | NAAA (0.48) | ALOX12HRH4HRH3NAAAIMPDH2 | |
| SCHEMBL7898979 | 0.79 | NAAA (0.48) | ALOX12HRH4HRH3NAAAIMPDH2 | |
| SCHEMBL11166909 | 0.77 | HPGD (0.45) | HRH4HRH3NAAAIMPDH2SMN1; SMN2 | |
| SCHEMBL7892936 | 0.77 | HPGD (0.45) | HRH4HRH3NAAAIMPDH2SMN1; SMN2 | |
| SCHEMBL7131909 | 0.76 | IMPDH2 (0.40) | HRH4IMPDH2HTTSMN1; SMN2ADRA2A | |
| SCHEMBL7131905 | 0.76 | IMPDH2 (0.40) | HRH4IMPDH2HTTSMN1; SMN2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6197797-B1 | ANTICANCER AGENTS; SKIN DISORDERS | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 2001-03-06 | — | — | US | disclosed |