Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.34 |
| ▸ | BCHE | P06276 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 4/20 | 0.34 |
| ▸ | HRH1 | P35367 | 4/20 | 0.34 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.32 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7896622 | 0.90 | CNR2 (0.35) | CNR2CACNA1BHRH2HRH1KLK5 | |
| SCHEMBL7891183 | 0.87 | PADI4 (0.40) | CNR2CACNA1BHRH2HRH1KLK5 | |
| SCHEMBL7896929 | 0.87 | CACNA1B (0.33) | CNR2CACNA1BHRH2HRH1KLK5 | |
| SCHEMBL7906019 | 0.86 | PDE2A (0.34) | CNR2CACNA1BHRH2HRH1KLK5 | |
| SCHEMBL7898758 | 0.84 | CNR2 (0.36) | CNR2HRH2HRH1KLK5REN | |
| SCHEMBL7891178 | 0.84 | CNR2 (0.36) | CNR2HRH2HRH1KLK5REN | |
| SCHEMBL7899697 | 0.83 | PROKR1 (0.39) | CNR2CACNA1BHRH2HRH1KLK5 | |
| SCHEMBL7901247 | 0.82 | CNR2 (0.33) | CNR2HRH2HRH1KLK5PTPN1 | |
| SCHEMBL2789237 | 0.81 | CNR2 (0.37) | CNR2REN | |
| SCHEMBL2788383 | 0.81 | KLK5 (0.36) | CNR2CACNA1BHRH2HRH1KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |