Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 4/20 | 0.33 |
| ▸ | HRH1 | P35367 | 4/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | CCNK | O75909 | 1/20 | 0.31 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.31 |
| ▸ | ACE | P12821 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7896929 | 0.93 | CACNA1B (0.33) | PDE2APDE3AHRH2HRH1CACNA1B | |
| SCHEMBL7901623 | 0.90 | ALOX5AP (0.33) | PDE2APDE3AHRH2HRH1CCNT1 | |
| SCHEMBL7896622 | 0.87 | CNR2 (0.35) | HRH2HRH1CACNA1BKLK5CNR2 | |
| SCHEMBL7891183 | 0.87 | PADI4 (0.40) | HRH2HRH1CACNA1BKLK5CNR2 | |
| SCHEMBL7901244 | 0.86 | HTR6 (0.34) | HRH2HRH1CACNA1BKLK5CNR2 | |
| SCHEMBL7901932 | 0.81 | PTGS2 (0.34) | HRH2HRH1CACNA1BKLK5CNR2 | |
| SCHEMBL7891178 | 0.81 | CNR2 (0.36) | HRH2HRH1KLK5CNR2PADI4 | |
| SCHEMBL7898758 | 0.81 | CNR2 (0.36) | HRH2HRH1KLK5CNR2PADI4 | |
| SCHEMBL7898298 | 0.81 | WNT3A (0.32) | PDE2APDE3AHRH2HRH1CCNT1 | |
| SCHEMBL7899697 | 0.81 | PROKR1 (0.39) | HRH2HRH1CACNA1BKLK5CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |