Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7905956 | 0.68 | PKM (0.33) | MDM2HSD17B10USP2ALDH1A1GAA | |
| SCHEMBL23030158 | 0.65 | KDM4E (0.36) | HSD17B10USP2ALDH1A1GAAKDM4E | |
| SCHEMBL3990187 | 0.64 | NPC1 (0.43) | ALDH1A1GAASMN1; SMN2NPC1RAB9A | |
| SCHEMBL5663279 | 0.64 | NPC1 (0.47) | ALDH1A1GAASMN1; SMN2NPC1RAB9A | |
| SCHEMBL3209050 | 0.64 | CYP11B2 (0.37) | HSD17B10ALDH1A1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL23029993 | 0.64 | KDM4E (0.41) | HSD17B10ALDH1A1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL7903218 | 0.62 | KDM4E (0.50) | KDM4ESMN1; SMN2CCR1CCR5CCR8 | |
| SCHEMBL6217374 | 0.62 | EGLN2 (0.41) | CHEK1LIMK1CLK4CCR1CCR5 | |
| SCHEMBL13939738 | 0.61 | CCR1 (0.31) | CCR1CCR5CCR8 | |
| SCHEMBL4572140 | 0.61 | DGAT1 (0.37) | ALDH1A1NPC1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021058595-A1 | HERBICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION AG (CH) | 2021-04-01 | — | — | WO | disclosed |
| US-8546406-B2 | Heterocyclic compounds as metap-2 inhibitors | MERCK PATENT GMBH (DE) | 2013-10-01 | — | — | US | disclosed |
| WO-2010083870-A1 | NOVEL HETEROCYCLIC COMPOUNDS FOR USE AS METAP-2 INHIBITORS | MERCK PATENT GMBH (DE) | 2010-07-29 | — | — | WO | disclosed |