Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.38 |
| ▸ | KAT7 | O95251 | 1/20 | 0.38 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7900422 | 0.78 | BTK (0.44) | GPR119BTKMEN1ALDH1A1MAPT | |
| SCHEMBL7900093 | 0.78 | BTK (0.44) | GPR119BTKMEN1ALDH1A1MAPT | |
| SCHEMBL7898292 | 0.74 | BTK (0.42) | GPR119BTKMEN1ALDH1A1MAPT | |
| SCHEMBL7891192 | 0.73 | USP30 (0.41) | GPR119BTKMEN1ALDH1A1MAPT | |
| SCHEMBL7899985 | 0.73 | USP30 (0.43) | GPR119BTKMEN1ALDH1A1MAPT | |
| SCHEMBL1866537 | 0.71 | ALOX5AP (0.57) | GPR119MAPTUSP30ACKR3JAK2 | |
| SCHEMBL1866539 | 0.71 | ALOX5AP (0.57) | GPR119MAPTUSP30ACKR3JAK2 | |
| SCHEMBL19405061 | 0.68 | GPR119 (0.52) | GPR119MAPTUSP30TRPV3HPGDS | |
| SCHEMBL1474817 | 0.68 | GPR119 (0.56) | GPR119BTKMEN1ALDH1A1MAPT | |
| SCHEMBL8234183 | 0.68 | GPR119 (0.55) | GPR119USP30ACKR3KAT7KAT8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |