Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7898292 | 0.84 | BTK (0.42) | BTKUSP30GPR119JAK2JAK1 | |
| SCHEMBL7901892 | 0.83 | MAPK1 (0.49) | USP30GPR119JAK2JAK1PRMT5 | |
| SCHEMBL7901506 | 0.78 | GPR119 (0.42) | BTKUSP30GPR119JAK2JAK1 | |
| SCHEMBL7898726 | 0.76 | USP30 (0.46) | USP30GPR119MEN1ALDH1A1MAPT | |
| SCHEMBL7900093 | 0.76 | BTK (0.44) | BTKUSP30GPR119JAK2JAK1 | |
| SCHEMBL19405061 | 0.72 | GPR119 (0.52) | USP30GPR119MAPTHPGDS | |
| SCHEMBL7901095 | 0.71 | HPGDS (0.46) | USP30GPR119JAK2JAK1PRMT5 | |
| SCHEMBL7899985 | 0.71 | USP30 (0.43) | BTKUSP30GPR119MEN1ALDH1A1 | |
| SCHEMBL25047542 | 0.70 | MEN1 (0.55) | USP30GPR119MEN1ALDH1A1MAPT | |
| SCHEMBL12808125 | 0.70 | MEN1 (0.55) | USP30GPR119MEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |