SCHEMBL790152

SCHEMBL790152

O=C(NC(=S)Nc1ccc2c(c1)OCCO2)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 14/20 1.00
NPC1 O15118 14/20 1.00
ALDH1A1 P00352 11/20 1.00
MAPT P10636 10/20 1.00
SMN1; SMN2 Q16637 10/20 1.00
ALOX12 P18054 6/20 1.00
GAA P10253 2/20 1.00
NFKB1 P19838 2/20 0.85
NFKB2 Q00653 2/20 0.85
RELA Q04206 2/20 0.85
CYP1A2 P05177 2/20 0.85
CYP3A4 P08684 2/20 0.85
CYP2C19 P33261 2/20 0.85
CYP2D6 P10635 1/20 0.85
CYP2C9 P11712 1/20 0.85
HPGD P15428 1/20 0.85
LMNA P02545 3/20 0.76
TDP1 Q9NUW8 2/20 0.72
MEN1 O00255 2/20 0.67
KMT2A Q03164 2/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12129932 0.88 NPC1 (0.78) RAB9ANPC1ALDH1A1MAPTSMN1; SMN2
SCHEMBL23114368 0.82 RAB9A (0.91) RAB9ANPC1ALDH1A1MAPTSMN1; SMN2
SCHEMBL22057898 0.81 ALDH1A1 (0.67) RAB9ANPC1ALDH1A1MAPTSMN1; SMN2
SCHEMBL22058802 0.80 ALDH1A1 (0.66) RAB9ANPC1ALDH1A1MAPTSMN1; SMN2
SCHEMBL24178873 0.80 ALDH1A1 (0.66) RAB9ANPC1ALDH1A1MAPTSMN1; SMN2
SCHEMBL5174923 0.78 NPC1 (0.84) RAB9ANPC1ALDH1A1MAPTSMN1; SMN2
SCHEMBL27181112 0.78 RAB9A (0.85) RAB9ANPC1ALDH1A1MAPTSMN1; SMN2
SCHEMBL30926503 0.78 RAB9A (0.85) RAB9ANPC1ALDH1A1MAPTSMN1; SMN2
SCHEMBL19337602 0.78 MAPT (0.63) RAB9ANPC1ALDH1A1MAPTSMN1; SMN2
SCHEMBL6295679 0.77 NPC1 (1.00) RAB9ANPC1ALDH1A1MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012037351-A1 COMPOUNDS GLAXOSMITHKLINE LLC (US) 2012-03-22 WO disclosed
WO-2012037349-A2 COMPOUNDS GLAXOSMITHKLINE LLC (US) 2012-03-22 WO disclosed