SCHEMBL19337602

SCHEMBL19337602

O=C(NC(=S)Nc1cccc(NC(O)c2ccccc2)c1)c1ccc2c(c1)OCCO2

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 12/20 0.63
SMN1; SMN2 Q16637 11/20 0.63
ALDH1A1 P00352 11/20 0.63
RAB9A P51151 10/20 0.63
NPC1 O15118 8/20 0.63
ALOX12 P18054 6/20 0.63
GAA P10253 1/20 0.63
MAPK1 P28482 2/20 0.61
STAT1 P42224 1/20 0.61
P2RX2 Q9UBL9 3/20 0.59
LMNA P02545 6/20 0.58
NRP1 O14786 1/20 0.56
NFKB1 P19838 2/20 0.55
NFKB2 Q00653 2/20 0.55
RELA Q04206 2/20 0.55
PKM P14618 1/20 0.55
MAOB P27338 1/20 0.55
HPGD P15428 4/20 0.54
CYP2C9 P11712 2/20 0.54
CYP2C19 P33261 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12129932 0.85 NPC1 (0.78) MAPTSMN1; SMN2ALDH1A1RAB9ANPC1
SCHEMBL790152 0.78 RAB9A (1.00) MAPTSMN1; SMN2ALDH1A1RAB9ANPC1
SCHEMBL827641 0.77 CCR2 (0.70) MAPTSMN1; SMN2ALDH1A1RAB9ANPC1
SCHEMBL19337872 0.74 P2RX2 (0.56) MAPTSMN1; SMN2ALDH1A1RAB9ANPC1
SCHEMBL18487975 0.73 NPC1 (0.79) MAPTSMN1; SMN2ALDH1A1RAB9ANPC1
SCHEMBL13684426 0.72 NRP1 (1.00) MAPTSMN1; SMN2ALDH1A1RAB9ANPC1
SCHEMBL29698045 0.72 NRP1 (1.00) MAPTSMN1; SMN2ALDH1A1RAB9ANPC1
SCHEMBL6180069 0.71 CCR2 (0.64) MAPTSMN1; SMN2ALDH1A1RAB9ANPC1
SCHEMBL5493789 0.70 CCR2 (0.63) MAPTSMN1; SMN2ALDH1A1RAB9ANPC1
SCHEMBL14364232 0.69 CCR2 (0.64) MAPTSMN1; SMN2ALDH1A1RAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2291352-B1 N-ACYLTHIOUREA AND N-ACYLUREA INHIBITORS OF THE HEDGEHOG PROTEIN SIGNALLING PATHWAY CENTRE NAT RECH SCIENT (FR) 2017-09-13 EP disclosed